Isomaltulose Preload Timing Modulates Incretin Response and Second Meal Effect in Metabolic Syndrome

Low-glycemic carbohydrate isomaltulose (ISO) supports incretin release and improves postprandial control via the second meal effect (SME), relevant for metabolic syndrome (MetS). In a randomized crossover trial, 15 MetS subjects received ISO or sucrose (SUC) preloads 1 h or 3 h before a test meal. ISO blunted glucose rise (ΔG/Δt: 0.28 vs. 0.53 mmol/L/min, p<0.01), sustained GLP-1 and PYY, while SUC drove higher GIP. Preload timing shaped outcomes: ISO at 3 h enhanced PYY and SME more than at 1 h. ISO, especially with a 3 h preload, shows potential to optimize postprandial glycemia in MetS.

Source: https://www.mdpi.com/2072-6643/17/15/2539