Gut Check After Transplant: Can Microbiome Therapy Reduce Immunosuppression Harm?

Improved surgery and immunosuppression have lengthened transplant survival, but chronic immunosuppressants cause frequent GI symptoms and long-term cardiometabolic risks (diabetes, dyslipidaemia, hypertension, malignancy). Emerging evidence links these harms to gut dysbiosis and increased intestinal permeability, which promote toxin production, bacterial translocation, and inflammation. Early studies testing diet, high‑dose synbiotics (prebiotics/probiotics/antibiotics) and fecal transplants suggest microbial modulation could restore barrier function, suppress pathogens, and lower systemic inflammation—but robust, controlled trials in transplant patients are still needed.

Source : https://pubmed.ncbi.nlm.nih.gov/36126902/