Hepatoprotective Effects of Mango Seed Polyphenols in Alcoholic Liver Disease & Modulation of Intestinal Flora

This study on Mangifera indica seed for their biological activities, particularly their ability to protect against alcoholic liver disease and modulate gut microbiota. The researchers separated mango seed components into different fractions and found that polyphenol-rich fractions containing compounds such as gallic acid, ellagic acid, and gallotannins exhibited the strongest antioxidant and anti-inflammatory effects. In an alcoholic liver disease model, these fractions reduced liver injury markers, oxidative stress, lipid accumulation, and inflammatory responses, while improving liver tissue structure and function. They also helped restore intestinal barrier integrity and beneficially altered the composition of the gut microbiota by increasing beneficial bacterial populations and reducing potentially harmful ones, indicating a liver-gut axis effect. Mango seed polyphenol-rich fractions exert hepatoprotective effects through antioxidant, anti-inflammatory, and gut microbiota-modulating actions.

Source : https://www.mdpi.com/2304-8158/15/7/1116