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Spermidine: The Polyamine with Potential for a Healthier Heart!

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Spermidine, a naturally occurring polyamine, shows promise in promoting heart health by potentially lowering cardiovascular disease (CVD) risk factors. A recent study utilizing a bi-directional Mendelian randomization approach found that higher spermidine levels are significantly associated with reduced risk of hypertension, lower blood glucose levels, and improved lipid profiles—demonstrated by decreased low-density lipoprotein cholesterol (LDL-C) and increased high-density lipoprotein cholesterol (HDL-C). Notably, elevated blood glucose was linked to lower spermidine levels, suggesting that while spermidine may positively influence CVD risk factors, high blood glucose could diminish its levels. These findings position spermidine as a potential dietary target for preventing and managing cardiovascular diseases.

Source: https://www.sciencedirect.com/science/article/pii/S0899900724001989?via%3Dihub

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