In the 12-week study involved 88 participants who received either MSM or a placebo. Each day, subjects took 10 tablets, each containing 200 mg of MSM or lactose and after 12 weeks, the MSM group exhibited significantly lower JKOM total scores compared to the placebo group, showed statistically lower health condition scores at 12 weeks, emphasizing improved knee health. The study emphasized the connection between knee osteoarthritis (KOA), inflammation, degenerative processes, and oxidative stress. The researchers noted that inflammatory changes can reduce antioxidant activity, increasing oxidative stress and impacting knee joint structural proteins. Though subjects weren’t diagnosed with KOA, their awareness of knee health deterioration suggested increased oxidative stress. The researchers highlighted MSM’s antioxidant activity and free radical scavenging. As MSM is known for its ability to combat oxidative stress, it’s speculated that this antioxidant property contributed to the enhanced quality of life for the knee joint. Eric Ciappio, PhD, RD, from Balchem expressed excitement about the study, emphasizing that OptiMSM showed efficacy at just two grams per day. This trial, conducted on healthy adults, expands the potential applications of OptiMSM beyond patients with osteoarthritis.