Effect of Soy Isoflavones on Facial Aging in Postmenopausal Women

A six-month randomized, double-blind controlled trial investigated the effects of a soy protein isolate enriched with 50 mg of isoflavones on facial aging and skin hydration in 44 postmenopausal women with Fitzpatrick skin types I–III. Compared to a casein control, the soy group showed significant improvements, including a 5.9% reduction in wrinkle severity by week 16, further improving to 7.1% by week 24, a 2.5% decrease in facial pigmentation, and notable increases in skin hydration—39% on the left cheek and 68% on the right. The observed benefits are attributed to the phytoestrogenic and antioxidant properties of soy isoflavones, which may enhance collagen synthesis, boost hyaluronic acid levels, and reduce melanin production. The supplement was well-tolerated, with only one withdrawal due to constipation linked to the casein group.

Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC10574417/