Coumarin: A natural solution for alleviating inflammatory disorders

Coumarin, a naturally occurring benzopyrone, exerts potent anti-inflammatory effects through multiple complementary mechanisms. Coumarin suppresses activation of the NF-κB, MAPK, JAK/STAT, and NLRP3 inflammasome pathways, thereby reducing the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), COX-2, iNOS, and reactive oxygen species (ROS), while enhancing endogenous antioxidant defenses. Across preclinical studies and limited clinical evidence, coumarin and its derivatives consistently attenuated inflammation, oxidative stress, and tissue injury, improving outcomes in disorders such as rheumatoid arthritis, inflammatory bowel disease, asthma, and other chronic inflammatory conditions.

Source : https://pmc.ncbi.nlm.nih.gov/articles/PMC11470182/