Sindbis Virus – Mediated Dual Approach: Oncolytic and Immunotherapeutic Strategy for Treating Pancreatic Cancer

The article explores the potential of using the Sindbis virus as a dual-function therapeutic agent against pancreatic cancer. Pancreatic cancer is notorious for its dense layer and immunosuppressive microenvironment, which hinder effective treatment. The study investigates the Sindbis virus’s ability to selectively infect and disintegrate pancreatic tumor cells (oncolytic activity) while simultaneously stimulating an anti-tumor immune response (immunotherapeutic effect). By leveraging these dual mechanisms, the Sindbis virus platform aims to disrupt the tumor’s protective microenvironment, enhance immune system recognition, and improve therapeutic outcomes. The findings suggest that this approach could offer a promising avenue for treating pancreatic cancer by combining direct tumor cell destruction with immune system activation.

Source: https://www.mdpi.com/1424-8247/18/5/725