A new wave of interest is building around S-equol, a soy-derived metabolite shown to significantly ease menopause symptoms—particularly in women who cannot naturally produce equol. Backed by multiple clinical trials, including a recent study in postmenopausal Japanese women reporting nearly 60% reduction in daily hot flashes, S-equol offers a targeted, non-hormonal alternative for managing vasomotor and mood-related symptoms.
What sets S-equol apart is its selective affinity for estrogen receptor beta (ERβ), allowing it to mimic estrogen’s benefits without stimulating tissues associated with hormonal cancer risks. This makes it a compelling innovation for formulators looking to develop safe, plant-based menopause support products that go beyond conventional isoflavones.
Source: https://www.sciencedirect.com/science/article/abs/pii/S0944711324001211
