Obesity and Metabolic Syndrome Limit Muscle Gains in Older Adults: Whey/Casein-Based Supplementation Shows Superior Results

A retrospective analysis of a randomized clinical trial examined how obesity and metabolic syndrome (MetS) affect muscle gains from resistance exercise and protein-based multi-ingredient supplementation (MIS) in older men. Obesity and MetS strongly predicted reduced improvements in lean mass, strength, and body composition, indicating anabolic resistance. In overweight/obese participants with MetS risk factors, whey/casein-based MIS (with creatine, vitamin D3, calcium, fish oil) led to significantly greater muscle mass, strength, performance, and bone turnover improvements than a collagen-based supplement. These findings suggest that high-quality dairy protein supplementation may better combat sarcopenic obesity and support musculoskeletal health in aging populations, despite adequate total protein intake.

Source: https://pubmed.ncbi.nlm.nih.gov/39771028/