N-acetylcysteine -Potential for Memory Enhancement

The study explores the cognitive-enhancing effects of N-acetylcysteine (NAC), a compound traditionally known for its antioxidant and mucolytic properties. Using adult male Albino Wistar rats, the study administered NAC at doses of 25, 50, and 100 mg/kg and assessed its impact on learning, memory, and behavior through various tests like the Morris Water Maze (MWM), Novel Object Recognition (NOR), open field test, elevated plus maze, and forced swim test. Results revealed that NAC significantly improved memory acquisition, retention, and recognition in a dose-dependent manner, with the 50 mg/kg dose showing optimal effects. It also found that NAC reduced anxiety-like behaviors and modulated dopamine and serotonin levels in the brain, suggesting its role in supporting cognitive function through neurotransmitter regulation. These findings highlight the promise of NAC as a repurposed therapeutic agent for enhancing memory and potentially addressing neurodegenerative or cognitive disorders.

Source: https://www.jnutraceutical.com/full-text/repurposing-n-acetylcysteine-unveiling-its-potential-for-memory-enhancement-in-animal-model