The Accelerated Ovarian Failure (AOF) rodent model more closely replicates human perimenopause and postmenopause than traditional models. Low-dose VCD injections gradually deplete ovarian follicles, producing fluctuating and eventually undetectable estrogen levels while preserving ovarian tissue. This model helps separate the effects of aging from hormonal decline and may advance research on menopause-related memory, mood, and other symptoms.
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