High‑Dose Vitamin D in Multiple Sclerosis: Safe, Immunomodulatory, Clinical Benefit Unclear

High‑dose vitamin D (≥10,000 IU/day) safely raises 25‑hydroxy vitamin D with rare transient calcium changes and shows consistent immunomodulatory effects, especially reduced IL‑17 activity-but clinical and MRI benefits remain inconsistent. Larger, longer trials are needed to confirm whether immune changes translate into reduced relapses or disability.

Source : https://pubmed.ncbi.nlm.nih.gov/42320168/