Skin Antiaging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial

This randomized, double-blind, placebo-controlled study demonstrated that the Skin Method serum and cream, containing proprietary hyaluronate, ectoin, active waters, and triglycerides, produced rapid and sustained improvements in skin health compared to placebo. Visible benefits such as wrinkle reduction, hydration, and radiance appeared within 1 hour of application, with significant enhancements in moisturization, smoothness, elasticity, firmness, and reduced transepidermal water loss at 4 and 8 weeks. The greatest effects were observed when the active cosmetics were combined with an oral probiotic supplement (L. plantarum, L. reuteri, L. rhamnosus, D-biotin, and Vitamin A), which outperformed placebo supplements and highlighted a synergistic effect between probiotics and topical products. Improvements were self-reported by up to 95% of participants, confirming that combined oral and topical treatment yielded superior results compared to either intervention alone.

Source : https://www.mdpi.com/2079-9284/12/2/34