Topical Geranium and Calendula Oils in Vesicular Formulations for Skin Aging

The study investigated Geranium essential oil (Pelargonium graveolens) and Calendula essential oil (Calendula officinalis) encapsulated in ethanolic lipid vesicles for topical delivery. The vesicular formulation enhanced the stability and skin penetration of volatile bioactive compounds, including citronellol, geraniol, and alpha pinene. By increasing diffusion through the stratum corneum, the vesicles allowed the active compounds to reach deeper skin layers, where they reduced oxidative stress and inhibited collagenase and elastase enzymes, protecting structural proteins and slowing skin aging. The vesicle based cream showed improved antioxidant activity, nitric oxide scavenging capacity, enzyme inhibition, and skin retention compared with non vesicular formulations. The study concluded that ethanolic lipid vesicles are a promising topical delivery system for essential oils, enhancing their anti aging effects and supporting their use in cosmetic and dermatological applications.

Source : https://pmc.ncbi.nlm.nih.gov/articles/PMC8452390/