Therapeutic Potential of Clitoria ternatea in Endometriosis

The study explores the therapeutic potential of Clitoria ternatea L. (Butterfly Pea) flower extract in managing endometrial pain. Phytochemical screening revealed alkaloids, flavonoids, glycosides, tannins, and steroids, and both in vitro and in vivo experiments showed strong anti-inflammatory and analgesic effects, with significant inhibition of heat-induced hemolysis, carrageenan-induced edema, and acetic acid-induced writhing in mice. Network pharmacology identified 92 overlapping targets between the extract’s compounds and endometrial pain-related genes, highlighting key proteins such as SRC, ESR1, and PI3KR1. Molecular docking and dynamics simulations further confirmed stable interactions between bioactive compounds and target proteins. Together, the findings suggest that Butterfly Pea extract may provide effective, plant-based relief from endometrial pain by modulating inflammatory and hormonal pathways.

Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC11595475/