The study on Centella asiatica significantly enhances diabetic wound healing by suppressing excessive macrophage driven inflammation and promoting tissue regeneration. Using pharmacological screening and cellular models that mimic the diabetic inflammatory environment, the researchers identified key bioactive compounds, including cynarine, quercetin, and kaempferol, which reduced nitric oxide production and downregulated pro inflammatory mediators such as iNOS, IL-1β, IL-6, and TNF-α while increasing anti-inflammatory cytokines like IL-4 and IL-10. Mechanistic analysis showed that these effects were mediated through inhibition of the AKT/MAPK/NF-κB signaling pathways, which play a central role in macrophage activation and chronic inflammation. In diabetic mouse models, topical application of Centella asiatica accelerated wound closure, improved granulation tissue formation, increased collagen deposition, enhanced angiogenesis via elevated VEGF-A expression, and reduced cell apoptosis. The findings provide strong evidence that Centella asiatica restores immune balance in diabetic wounds and supports its potential as a therapeutic agent for managing chronic, inflammation driven wound healing complications.
Source : https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1632573/full
