Protective Role of Microsorum scolopendria against Staphylococcal Infection-Induced Oxidative Stress and Inflammation

The study explores the biological activity of hexane extracts obtained from the leaves (HH) and rhizomes (RH) of the fern Microsorum scolopendria, focusing on their safety and protective potential in skin-related conditions. Both extracts were found to be non-toxic at concentrations up to approximately 100 µg/mL and demonstrated the ability to shield human dermal fibroblasts exposed to infections caused by Staphylococcus aureus and Staphylococcus epidermidis. Treatment with the extracts significantly reduced the accumulation of intracellular reactive oxygen species (ROS) and lowered the release of lactate dehydrogenase (LDH), a marker of cell damage, suggesting strong antioxidative and cytoprotective effects. Additionally, the extracts displayed selective inhibition of COX-2 over COX-1, indicating a targeted anti-inflammatory response. Chemical profiling revealed the presence of bioactive compounds such as phenolic acids, flavonoids, stilbenes, and other polyphenols, which are likely responsible for these beneficial actions. Findings suggest that the therapeutic relevance of M. scolopendria extracts not only in reducing infection-induced oxidative stress and inflammation but also in supporting skin health. Their potential applications may include use in dermatological treatments for inflammatory or infectious conditions, as well as in cosmetic or skin care formulations aimed at enhancing cell protection, promoting wound repair, and combating aging-related oxidative damage.

Source: https://www.mdpi.com/2076-3921/14/10/1194