The study evaluated the root extract of Paeonia lactiflora, standardized for paeoniflorin, for its ability to modulate inflammation and protect tissue integrity in skin keratinocytes and oral gingival fibroblasts under inflammatory conditions. Using lipopolysaccharide (LPS) induced in vitro models along with in silico analysis, the extract reduced the activity of TRPV1 channels and lowered the production of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-13. It also inhibited matrix-degrading enzymes including MMP-9 and MMP-8, thereby preventing collagen breakdown and supporting the maintenance of type I collagen. These combined effects helped reduce inflammatory stress and preserve tissue structure. Hence, Paeonia lactiflora extract has strong anti-inflammatory and tissue-protective properties, indicating its potential use in dermatological and oral care applications.
Source : https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1625451/full#s4
