The review details nanoencapsulation platforms (lipid nanoparticles, nanoemulsions, and biopolymer-based carriers) that protect labile nutraceuticals from physicochemical degradation and enhance dispersion and gastrointestinal stability within functional food systems. It outlines mechanistic improvements in oral bioavailability through increased solubility, controlled release kinetics, mucoadhesion, cellular uptake, and partial circumvention of first-pass metabolism via lymphatic transport. The paper also addresses translational challenges including scale-up feasibility, safety evaluation, regulatory constraints, and emerging strategies such as co-encapsulation for synergistic delivery.
Source : https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1746176/full
