Multivitamins May Slow Biological Aging: New Evidence from DNA Epigenetic Clocks

A daily multivitamin–multimineral (MVM) could do more than just fill nutrient gaps, it may subtly slow the biological aging process at the DNA level. In the COSMOS trial, 2 years of supplementation with Centrum Silver showed modest but statistically significant reductions in the progression of key epigenetic aging markers like PCGrimAge and PCPhenoAge, particularly in individuals already experiencing accelerated biological aging. Interestingly, cocoa flavanols, despite their known cardiometabolic benefits did not influence these aging clocks, suggesting that broad-spectrum micronutrient sufficiency may play a more direct role in maintaining genomic stability. While the magnitude of effect is small, this study adds a compelling layer to the longevity narrative: optimizing micronutrient status could be a foundational, scalable strategy to nudge the biology of aging in a favorable direction, warranting deeper exploration into its long-term clinical impact.

Source : https://www.nature.com/articles/s41591-026-04239-3