A 6-week Stanford–Abbott trial in 89 older adults (avg. 67 yrs) found that supplementation with the human milk oligosaccharide 2′-fucosyllactose (2′-FL) boosted Bifidobacterium growth in the gut and improved several metabolic markers including higher insulin, HDL cholesterol, and FGF21 levels.
“Responders” with increased Bifidobacterium showed enhanced metabolic and proteomic profiles and performed better on visual memory tests. Multi-omics data revealed systemic effects of 2′-FL across blood and urine, underscoring its potential as a prebiotic for healthy aging and cognitive support.
Source : https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791%2825%2900329-5?
