A groundbreaking study has unveiled a significant genetic component in how professional football players respond to creatine supplementation, potentially impacting muscle mass, body mass index (BMI), and injury risk. Researchers analyzed six muscle performance-related gene polymorphisms, including ACE I/D and AMPD1 c.34C>T, in 161 male athletes. The study revealed that those with favorable genetic profiles—specifically, a total genotype score (TGS) above 54.16 a.u.—were nearly three times more likely to experience an increase in muscle mass after a creatine regimen. Conversely, players with a TGS below 54.16 a.u. had a markedly higher risk of non-contact muscle injuries. Notably, the AMPD1 CC genotype and C allele were strongly linked to greater muscle mass gains. This pioneering research highlights the importance of personalized supplementation strategies in enhancing athletic performance and minimizing injury risk.
CV Sciences Launches Cannabinoid-Free +PlusHlth Supplements
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