A groundbreaking study has unveiled a significant genetic component in how professional football players respond to creatine supplementation, potentially impacting muscle mass, body mass index (BMI), and injury risk. Researchers analyzed six muscle performance-related gene polymorphisms, including ACE I/D and AMPD1 c.34C>T, in 161 male athletes. The study revealed that those with favorable genetic profiles—specifically, a total genotype score (TGS) above 54.16 a.u.—were nearly three times more likely to experience an increase in muscle mass after a creatine regimen. Conversely, players with a TGS below 54.16 a.u. had a markedly higher risk of non-contact muscle injuries. Notably, the AMPD1 CC genotype and C allele were strongly linked to greater muscle mass gains. This pioneering research highlights the importance of personalized supplementation strategies in enhancing athletic performance and minimizing injury risk.
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