This review establishes a “metabolic code” where Lactobacillus-derived metabolites, specifically SCFAs, function as epigenetic and signaling ligands that directly regulate bone remodeling via the activation of GPR41, GPR43, and GPR109A. The authors demonstrate that these microbial-host interactions suppress osteoclastogenesis by modulating the RANKL/OPG ratio and reducing systemic pro-inflammatory cytokines such as TNF-α and IL-6. Furthermore, the study identifies these metabolic pathways as critical therapeutic targets, providing a mechanistic framework for using specific probiotic consortia to enhance bone mineral density and prevent metabolic bone diseases.
Source : https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1553655/full
