Cyperus rotundus Piperine Blend Reduces Weight and Improves Lipids in Obesity

A 90-day randomized placebo-controlled trial tested a standardized Cyperus rotundus extract with piperine (CREP) in 96 obese adults. Twice-daily dosing produced meaningful reductions in body weight (7.1%), BMI (6.9%), WC (6.8%), and hip circumference (6.6%), suggesting a positive effect on abdominal obesity. Weight loss of 5% or more is considered clinically meaningful for improving metabolic health, and in this study, 43 of 48 participants (89.5%) in the CREP group achieved this threshold, compared to only 6 of 48 participants (12.5%) in the placebo group. This highlights the significant impact of CREP on body weight reduction beyond lifestyle measures alone. Lipid markers and ApoB-100 improved in parallel, suggesting better metabolic control. Safety markers stayed normal and no adverse events occurred. The data indicate that CREP supports abdominal fat reduction and metabolic health, positioning it as a promising natural aid for weight management.

Source : https://journals.lww.com/md-journal/fulltext/2025/11210/efficacy_and_safety_of_cyperus_rotundus_extract_on.34.aspx