The study investigated the biological potential of the bark extract of Anadenanthera colubrina. The researchers prepared a hydroethanolic extract and evaluated its phytochemical content and bioactivity. The extract showed high total phenolic content (642.7 mg gallic acid equivalents per gram) and total flavonoid content (416.2 mg catechin equivalents per gram), indicating a rich presence of antioxidant compounds. It demonstrated strong antioxidant effects, reflected in high DPPH radical scavenging activity (747.6 mg Trolox equivalents per gram) and ferric reducing antioxidant power (435.9 mg FeSO₄ equivalents per gram). In anti-inflammatory assays, the extract inhibited lipid peroxidation, hydrogen peroxide-induced hemolysis, and protein denaturation, supporting its role in protecting against oxidative and inflammatory stress. However, no effect was observed in hypotonicity-induced hemolysis, suggesting that its anti-inflammatory activity may be mechanism-specific. Overall, the findings suggest that Anadenanthera colubrina possesses potent antioxidant and anti-inflammatory properties due to its high phenolic and flavonoid contents.
Source : https://www.biorxiv.org/content/10.1101/2025.01.24.633472v1.full
