The study investigated the anti-obesity effects of red-skin extracts of lotus seeds in high-fat diet induced obese mice. Lotus seed red skin contains various bioactive compounds, particularly phenolic compounds. The results showed that the extract significantly reduced body weight gain and fat accumulation. It also improved lipid metabolism by regulating lipoprotein lipase (LPL) activity. The extract decreased LPL activity in adipose tissue and increased its activity in skeletal muscle. It also helped reduce serum triglyceride and cholesterol levels. These findings suggest that lotus seed red-skin extract has potential as a natural ingredient for preventing obesity and regulating lipid metabolism.