This 12-week randomized, double-blind, placebo-controlled clinical trial evaluated an oral skincare supplement containing low molecular weight hyaluronic acid (sodium hyaluronate) and wheat oil extract in healthy adults. Hyaluronic acid enhanced skin hydration by increasing water retention within the extracellular matrix, while wheat oil extract supplied lipid components that strengthened the skin barrier and reduced transepidermal water loss. Participants receiving the supplement showed significant improvements in crow’s feet wrinkles, facial and overall skin smoothness from week 8 onward, with continued benefits through week 12. The intervention also produced significant increases in skin hydration and elasticity, and dermatologist assessments confirmed reductions in both fine and deep wrinkles by week 12. In addition, a significantly greater proportion of participants reported improvements in skin radiance, elasticity, fine lines, wrinkles, and overall skin appearance compared with the placebo group. The combination of oral hyaluronic acid and wheat oil extract improves multiple signs of skin aging.
Source : https://link.springer.com/article/10.1007/s13555-025-01556-2
