Avocado peel derived nutraceutical demonstrates a promising multi-targeted approach in managing Rheumatoid Arthritis while simultaneously mitigating associated Cardiovascular Disease risk. Rich in bioactive compounds with strong antioxidant capacity, APN effectively reduces oxidative stress, systemic inflammation, and dyslipidemia, key drivers linking RA to cardiometabolic complications. Mechanistically, it downregulates pro-inflammatory mediators such as COX-2, IL-6, IL-1β, and TNF-α, while enhancing anti-inflammatory IL-10 expression, indicating immune modulation at a genetic level. Additionally, APN supports gut microbiota rebalancing, restoring eubiosis and further contributing to improved immune and metabolic outcomes. Molecular docking insights suggest that phytoconstituents like β-amyrin and ellagic acid may exert therapeutic effects via interaction with immune-regulatory targets such as PTPN22.
Source : https://pubs.rsc.org/en/content/articlelanding/2026/fb/d5fb00656b
