Therapeutic potential of Pithecellobium dulce extract in Antioxidant, Wound Healing & Anticancer Applications

This study explored the methanolic extract of Pithecellobium dulce to evaluate the phytochemical composition and its potential role in antioxidant activity, wound healing, and anticancer applications. The analysis identified a range of bioactive compounds, including flavonoids, alkaloids, tannins, saponins, and phenolic acids, along with kaempferol-3-O-rhamnoside (afzelin), fisetin 3-O-rhamnoside, and alangilignoside D with high concentration levels. The extract showed strong antioxidant activity in DPPH and ORAC assays indicating its ability to neutralize oxidative stress. It also supported effective wound healing capability around 78% wound closure within 72 hours suggesting enhanced tissue repair. In anticancer studies, the extract demonstrated significant cytotoxic effects particularly against the HeLa cervical cancer cell line, and molecular docking further showed interactions with cancer related targets like BCL-2 and EGFR, which are involved in cell survival and proliferation. Overall, Pithecellobium dulce extract has potential effects due to its combined antioxidant, wound healing, and anticancer properties.

Source : https://www.nature.com/articles/s41598-025-32257-7