Akkermansia Benefits Depend on Baseline Gut Levels

In a 12-week trial in overweight/obese type 2 diabetes patients, Akkermansia supplementation showed metabolic benefits only in those with low baseline gut levels. These participants had reduced body weight, fat mass, and HbA1c. No benefit was seen in those with already high baseline levels. Effects depend on initial gut microbiota status.

Source : https://pubmed.ncbi.nlm.nih.gov/39879980/