This study investigated the probiotic strains Lacticaseibacillus paracasei L9 and Bifidobacterium animalis subsp.lactis A6 for their potential to improve Alzheimer’s disease (AD) pathology through modulation of the gut brain axis in an AD mouse model. Oral administration of these probiotics improved learning and memory performance and helped restore hippocampal neuronal structure. The treatment reduced amyloid-β deposition and Tau protein hyperphosphorylation by regulating GSK-3β and PP2A activity, while also reshaping gut microbiota composition by reducing harmful bacteria such as Desulfovibrio and increasing beneficial microbial populations. Metabolomic analysis showed improvements in lipid-related metabolic pathways, indicating systemic metabolic regulation linked to neuroprotection. Overall, supplementation with Lacticaseibacillus paracasei L9 and Bifidobacterium animalis subsp. lactis A6 demonstrated neuroprotective effects and may represent a promising nutraceutical strategy for supporting cognitive health and slowing Alzheimer’s related neurodegeneration.
Source : https://www.sciopen.com/article/10.26599/FSHW.2024.9250340?issn=2097-0765
