This study describes the development of a multifunctional microneedle platform designed to overcome the poor healing seen in diabetic wounds, which is largely driven by chronic inflammation, oxidative stress, and infection. The researchers created a hydrogel based microneedle patch (HAQA-MN) loaded with kinsenoside that was coated with a macrophage membrane (M-KD), allowing the treatment to specifically target inflammatory macrophages within the wound environment. Once delivered, kinsenoside reprogrammed pro inflammatory M1 macrophages into a healing oriented M2 state by suppressing the IRE1α/XBP1/HIF-1α signaling pathway, leading to reduced glycolysis, improved mitochondrial oxidative phosphorylation, and overall dampening of inflammatory responses. The microneedle patch showed good biocompatibility, mechanical stability, and controlled release of the active compound, while also providing antimicrobial activity against Escherichia coli and Staphylococcus aureus and reducing oxidative stress by scavenging hydrogen peroxide. These findings demonstrate that minimall invasive delivery of kinsenoside via microneedles can restore immune balance at the wound site, create a favorable environment for tissue regeneration, and represents a promising, practical therapeutic strategy for managing chronic diabetic wounds.
Source : https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202502293
