Researchers are exploring how nature and nanotechnology can join forces to combat acne-causing bacteria and support wound healing. In this study, scientists used Plectranthus aliciae, a South African plant, along with its key compound rosmarinic acid and the antibiotic tetracycline to create gold nanoparticles. These tiny particles were tested for their stability, antibacterial activity, and ability to accelerate wound repair. Although the nanoparticles did not show significant effects against biofilm-forming acne bacteria such as Cutibacterium acnes and Staphylococcus epidermidis, those synthesized with rosmarinic acid notably enhanced wound closure in laboratory tests. The findings suggest that green-synthesized gold nanoparticles, especially those using rosmarinic acid, hold promise for future wound-healing therapies.