Urolithin A Shown to Rejuvenate Immune Cells and Combat Age Related Immune Decline

A new clinical study has found that Urolithin A (UA), a natural compound known for enhancing mitochondrial health, may help reverse age related immune decline. In a randomized, double blind, placebo controlled trial involving 50 healthy middle-aged adults, participants who received 1,000 mg of oral UA daily for four weeks showed significant improvements in immune cell function compared to placebo. UA supplementation expanded naïve and memory like CD8+ T cells while reducing immune cell exhaustion and boosting mitochondrial activity and fatty acid oxidation. It also increased active natural killer (NK) cells and beneficial monocytes, leading to improved immune responsiveness, including higher TNF secretion and better bacterial clearance. Gene expression analyses revealed broad metabolic and anti inflammatory effects across immune populations. These findings suggest that short term UA supplementation can rejuvenate immune cell metabolism and function, offering a promising nutritional approach to counteract immune aging and chronic inflammation.

Source : https://www.nature.com/articles/s43587-025-00996-x