In a randomized, double-blind study of individuals recovering from moderate COVID-19, a single 50 mg dose of a plant-based supplement (PB-Blend) significantly reduced mitochondrial ROS (−56%), iNOS (−60%), and NOX2-dependent ROS (−49%), while increasing bioavailable nitric oxide (+33%)—effects broader than those of 1000 mg Vitamin C. PB-Blend also improved inflammatory and immune markers, indicating it may be a potent natural aid for immune recovery and oxidative balance after viral infections.