Dehydroeburicoic Acid – Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease

The recent study on a compound called Dehydroeburicoic Acid (DEA), a triterpenoid found in the fungus Antrodia cinnamomea. It identifies DEA as a potential therapeutic agent for Alcoholic Liver Disease (ALD). The research reveals that DEA acts as a dual inhibitor,uniquely targeting two key cellular pathways: the Keap1-Nrf2 protein-protein interaction (PPI) and glycogen synthase kinase 3β (GSK3β). By disrupting the Keap1-Nrf2 interaction and inhibiting GSK3β, DEA promotes the movement of the Nrf2 protein into the cell’s nucleus. Once there, Nrf2 activates genes that produce antioxidants, which helps to restore mitochondrial function and reduce oxidative stress in liver cells affected by ALD.

Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC9866905/